|Dra. Paula G. Vissio
Investigadora Adjunta CONICET Profesora Adjunta DBBE-FCEN
The main objective of the Laboratory of “Neuroendocrinology of Growth and Reproduction” is to study the relationship among feeding, reproduction and somatic growth. Our experimental model is the social cichlid fish Cichlasoma dimerus, which demonstrated to be an excellent model for studies in neuroendocrinology and endocrinology of somatic growth and reproduction.
Two main lines of research are developed in our laboratory
-“Effects of food restriction over reproductive parameters”
In this project we study the impact of food restriction on hypothalamic hormones (GnRHs, NPY, and kisspeptinas GnIH), gonadotropins (LH and FSH), sex steroids, and gonadal histology. In addition, we are studying leptin, a hormone that acts as a link between nutritional status and reproduction in mammals, yet is not clear its role in fish.
In parallel, we conduct bioinformatic and phylogenetic studies that allow us to postulate hypothesis beyond our biological model.
-“ Response of GH / IGF axis to growth impairment following a food deprivation period and refeeding”
Growth hormone (GH)/insulin-like growth factor I (IGF-I) axis is the key regulator of somatic growth in vertebrates. Two types of growth hormone receptors have been described in teleost fish (GHR1 and GHR2), although its specificity is under debate. We are studying the changes in the GH/IGF-1 system that underlies growth after a period of food restriction and subsequent refeeding.